Technical Screening Scientist (100%)

Identify new antibody fragments to generate first in-class immune-oncology drugs

You will play an important role in the screening and hit identification of antibodies and antibody-derived molecules while collaborating with colleagues to deliver first-in-class biologics. In addition, you will help to drive innovative approaches for drug discovery using novel antibody and protein engineering technologies. We are looking for a highly motivated and collaborative team member with a passion for drug discovery research, who enjoys working in a fast-paced and highly dynamic working environment.

Responsibilities

• Execute and support antibody screening campaigns
• Perform phage display antibody library generation and selection
• Plan and execute molecular cloning activities
• Oversee ELISA-based binding characterization assays
• Perform FACS-based B-cell sorting and contribute to the development of the screening platform
• Cultivation and characterization of isolated B-cells
• Support activities for the design and optimization of antibody candidates
• Ensure best practices of research, data management and archiving
• Proactively prepare and/or organize required equipment, consumables and reagents

Your Profile

• Apprenticeship, B.Sc. or MSc. in biology, biochemistry, immunology, or a related discipline
• Demonstrated expertise in antibody display techniques (e.g. phage, yeast or mammalian)
• Expertise in molecular biology and cell culture techniques
• Experience with ELISA assays for antibody characterization
• Laboratory experience in flow cytometry or FACS-based cell sorting is a plus
• Experience with antibody affinity maturation and antibody humanization would be a plus
• Experience in recombinant protein production using mammalian cells would be a plus
• Ability to work independently and well-organized in a team environment
• Positive and proactive mindset