kLa Determination Workshop

Course Overview
The volumetric mass transfer coefficient, kLa, is an important parameter in many bioprocesses. It describes the rate at which a gaseous compound, such as oxygen, transfers between the gas phase and the liquid phase. The kLa Determination Workshop is designed for anyone interested in gaining deeper insights into the gas transfer characteristics of bioreactor systems and learning how to optimize parameters that influence kLa.

Participants will benefit from expert-led sessions covering both theoretical foundations and practical applications. The workshop also offers hands-on experience in experimentally determining kLa values in lab-scale bioreactors using state-of-the-art equipment and facilities at the Department of Biotechnology of TU Delft. The course concludes with a live demonstration of an innovative, fully automated method for determining kLa in bioreactors.

Key takeaways

• Gaining a deeper understanding of the key parameters that influence gas transfer in bioreactor systems
• Acquiring hands-on experience in experimentally determining and calculating kLa values of lab-scale bioreactors
• Participating in a live demonstration of a novel, fully automated method for determining and calculating kLa values

Key topics

• Gas Transfer in Bioreactor Systems: A comprehensive overview of the principles underlying gas transfer in bioreactors, including parameters that influence kLa and various methods for determining kLa. The theoretical sessions are presented by members of the Cees Haringa group from the Bioprocess Engineering section at TU Delft.
• kLa Determination Practical: A hands-on session focused on experimentally determining kLa values using the Static Gassing-Out method, followed by manual calculation. The practical is held in the education fermentation lab at the TU Delft Department of Biotechnology, with each participant operating their own dedicated bioreactor.
• Fully Automated kLa Determination: A demonstration of the Lucullus® application developed by Securecell, which autonomously performs kLa determination experiments and calculates the resulting kLa values.

What is included

• Online access to all theoretical material used during the course
• Certificate of attendance
• Lunch

How to register
To register, please fill out the provided form. Our team will then email you to provide details about the planning, accessibility of the location, and payment procedure.

If you wish to register a group of people, please specify the number of participants in the registration form.

We offer a special 20% discount for university students and PhD candidates. Please indicate your student status when filling out the registration form. Additionally, submission of your Student ID is required for verification purposes.