Monte Rosa Therapeutics is looking for an experienced, energetic, and self-motivated scientist with expertise in biology and translational research to join our team in Basel to work on the discovery and characterization of novel cancer medicines. At Monte Rosa we are taking a rational approach to targeting disease-causing proteins for degradation by means of molecular glue degraders (MGD). Protein degradation as a therapeutic modality can markedly extend the target space, allowing us to attack proteins with a strong link to human disease that were previously deemed undruggable. Our team combines deep knowledge and outstanding skills in the areas of chemistry, structural and cell biology, computational modeling and translational science to deliver pioneering degrader therapeutics for cancer and other diseases.
In this position within the Target Biology and Translational Research group, the candidate will provide scientific leadership to understand the biology of drug targets and apply that understanding to the identification and translation of novel degraders in biomarker-selected patients. The candidate will direct pharmacology studies and translational research in collaborative efforts with the preclinical team and the clinical team. The role will involve significant interaction and collaboration within the company and with external partners.
This position offers the opportunity to contribute to both drug discovery and clinical projects in an innovative and fast-paced team environment with tremendous growth opportunity. The candidate will have a passion for bringing innovative therapeutics to patients in need.
Main Duties and Responsibilities
Co-lead interdisciplinary project teams and work with a team of scientists to support biology of the target, the selection of lead candidate molecules and transition into clinical development.
Independently coordinate both internal and external (CRO) activities to optimize compound selection and explore the full therapeutic potential of drug targets.
Design and develop in vitro and in vivo assays to define mechanism of action for compounds, identify pharmacodynamic assays with utility in pre-clinical and clinical setting, and test patient selection strategies.
Direct supervision of a group of scientists performing cell biology and in vivo pharmacology studies
Play a leading role in the Drug Discovery and Translational group by sharing ideas, data, and working closely with colleagues to ensure success of entire portfolio.
Interface with external KOLs for input on disease hypothesis, translational models, clinical and regulatory landscape.
Assist in the management of program budget and deliverables.
Communicate data and strategies effectively to key stakeholders, including internal team members, senior management, and external partners
Skills and Qualifications
PhD or equivalent in biology, pharmacology, or related discipline with 5+ years of relevant drug discovery/translational research experience in the biotech/industry and/or academic institutions
Experience in oncology cell biology and in vivo preclinical models to enable the development of novel small molecule glue degraders
Track record of delivering candidate selection and in supporting IND filing would be an advantage
Experience overseeing the development of relevant models by using new technologies, such as CRSPR, to engineer cell lines
Demonstrated ability to use strong science to guide strategic direction
Proven track record of striving for high level of inter-disciplinary problem solving, innovation and scientific excellence
Demonstrated experience managing and leading teams, both directly and in matrix organizations
Proven time management skills and ability to support multiple projects
Strong strategic and critical thinking skills, with a demonstrated ability to analyze, interpret, and clearly communicate (written and oral) complex data and its impact on program strategy
Apply www.monterosatx.co or forward CV Careers-basel@Monterosatx.com