Scientist/Senior Scientist, Medicinal Chemistry Projects & Programs
Location: Basel, Switzerland
Monte Rosa is seeking an enthusiastic and highly talented chemist who is eager to advance molecular glue degraders (MGDs) as an emerging modality to drug undruggable proteins. This Basel-based position offers an exciting opportunity to be an integral member of a team of medicinal chemists at the cutting edge of drug discovery. The successful candidate will drive the medicinal chemistry of our highly innovative research programs to deliver MGD drug candidates in a fast-paced, intellectually stimulating and dynamic environment. Together, we discover the science of molecular glues that eliminate disease-causing proteins once thought impossible to touch.
Principal Duties and Key Responsibilities
Contribute to the design of novel, active, and proprietary MGDs following given SAR patterns or developing these from data at hand, while utilizing state-of-the-art medicinal chemistry knowledge
Closely follow emerging results of biological testing and ADME characterization to proactively propose new strategies and design new target molecules to improve compound properties
Execute the syntheses of MGDs using our CRO network
Work very closely and collaboratively with our interdisciplinary team of scientists to ensure timely and reliable delivery of project and pipeline objectives.
Summarize and publish research in publications and patents
Job Requirements
PhD in synthetic organic chemistry or medicinal chemistry
Post-Doc experience is preferred and 2 to 5 years of experience in the pharmaceutical industry and/or biotech is required
Familiarity with key concepts and optimization strategies in medicinal chemistry including a clear understanding of ADME properties
Strong background in complex molecule synthesis and/or methods development experience with a wide range of techniques related to synthesis, purification, and analysis
Basic understanding of disease biology and familiarity with all stages of pre-clinical research in drug discovery
Proven track record of productive research/discoveries through publications and/or patents
Familiarity with databases and data analysis tools
Excellent written and oral communication skills in English
Experience of collaborating with CROs is a plus
Familiarity with molecular modelling software (e.g., Maestro) is a plus
Interested Candidates should forward CV and, Cover letter and Publication list at Careers-Basel@monterosatx.com or apply on line at www.monterosatx.com
Basel, Switzerland