Indivior investment reflects progress towards clinical evaluation and validates power of allosteric platform
Therapeutics (SIX: ADXN), a leading allosteric modulation-based drug discovery and development company, today announced that Indivior PLC (LON: INDV) will provide Addex with an additional USD 800,000 in 2019 to accelerate research progess in their collaboration to develop further oral gamma-aminobutyric acid subtype B (GABAB) positive allosteric modulator (PAM) compounds for the treatment of addiction. Under the terms of the original agreement signed with Indivior in January 2018, Addex received a USD 5 million upfront and a minimum of USD 2 million per year of research funding for 2 years. Activation of the GABAB pathway is clinically and commercially validated but to date treatment is limited due to side effects. Targeting GABAB with PAMs could produce less adverse effects and lead to less tolerance compared to direct agonists.
Addex has made significant progress in the development of a series of novel GABAB PAMs for the treatment of addiction. The program is currently in late lead optimization and aims to deliver drug candidates by the end of 2020. In parallel, Addex is developing a separate GABAB PAM for the treatment of Charcot-Marie-Tooth type 1a (CMT1A) neuropathy, a rare inherited disorder that affects the periphery nerves.
“This additional investment by Indivior into the GABAB PAM addiction program reflects the significant progress we have made and provides additional support as we advance towards selecting drug candidates,” said Tim Dyer CEO of Addex. “This partnership illustrates well the power of our allosteric modulator discovery platform which has, in a very short period of time, been able to produce multiple potential drug candidate that are now being optimized for clinical evaluation.”